Mathematical ability and autism
Aims:
To test the genetic basis of mathematical ability.
Background:
This genetic study is testing for differences between mathematicians and non-mathematicians. Mathematicians have been chosen as clear examples of individuals who are talented at systemising. This builds on our earlier genome wide association study but uses next generation whole genome sequencing, in collaboration with Illumina Inc. Also, because autism occurs at a higher rate in mathematicians than would be expected by chance, we will be testing for genetic overlap with autism.
Method:
Whole genome sequencing and Sanger sequencing (a particular method of sequencing DNA).
Results:
These will appear on our website.
Importance:
This is of interest in its own right, but any overlap between the genetics of mathematical ability and the genetics of autism will change our view of both.
Relevance:
This research is mostly of relevance to the field of genetics but may also help to change the way society views autism, from a disabling condition to a neurological profile that may also be related to talent.
Selected Publications
- Genetics of Mathematical Aptitude, eLS DOI: 10.1002/9780470015902.a0026848 (2016), V Warrier, S Baron-Cohen
- Autism, maths, and sex: the special triangle, The Lancet Psychiatry 2:790-791 (2015), S Baron-Cohen
- A Genome Wide Association Study of Mathematical Ability Reveals an Association at Chromosome 3q29, a Locus Associated with Autism and Learning Difficulties: A Preliminary Study, PLoS ONE 9(5):e96374 (2014), S Baron-Cohen, L Murphy, B Chakrabarti, I Craig, U Mallya, S Lakatos, K Rehnstrom, L Peltonen, S Wheelwright, C Allison, S Fisher, V Warrier
- Why so few women in maths and science?, (2009), S. Baron-Cohen
- Mathematical Talent is Linked to Autism, Human Nature 18:125-131 (2007), S. Baron-Cohen, S. Wheelwright, A. Burtenshaw and E. Hobson
- The Autism Spectrum Quotient (AQ) : Evidence from Asperger Syndrome/High-Functioning Autism, Males and Females, Scientists and Mathematicians, Journal of Autism and Developmental Disorders 31:5-17 (2001), S. Baron-Cohen, S. Wheelwright, R. Skinner, J. Martin and E. Clubley
Staff:
- Professor Sir Simon Baron-Cohen
- Dr Carrie Allison
- Dr Rosie Holt
- Dr Ravi More
- Dr Varun Warrier
- Paula Smith
Funders:
- Templeton World Charity Foundation
- Autism Research Trust (This charity closed in 2023 and was replaced by the Autism Centre of Excellence)
- Wellcome Trust